Eczema, also known as atopic dermatitis, such as dyshidrotic eczema, nummular eczema or eczema herpeticum, is a common skin condition characterized by itchy, inflamed, and irritated skin.

While it is widely recognized that eczema can be triggered by allergies and asthma, there are several other health conditions that may seem unrelated but have been found to have unexpected links to this dermatological condition.

In this article, we will delve into the lesser-known associations between eczema and various conditions, ranging from infections and autoimmune diseases to heart disease and obesity.

We will also explore the potential mechanisms behind these connections, emphasizing the importance of identifying underlying causes for eczema flares and seeking medical assistance when triggers remain unidentified.

1. Infections: Staph, Herpes, and Cellulitis

Beyond the commonly recognized triggers, certain infections have been found to be linked to eczema.

Staphylococcus aureus (Staph) and Herpes simplex virus infections can exacerbate eczema symptoms and lead to more severe flare-ups.

Additionally, cellulitis, a bacterial skin infection, has been associated with eczema due to compromised skin barrier function.

2. Cardiovascular Conditions: Angina, Heart Disease, Heart Attack, and Heart Failure

Studies have demonstrated a correlation between eczema and cardiovascular conditions such as angina, heart disease, heart attack, and heart failure.

While the exact mechanisms are not fully understood, chronic inflammation, oxidative stress, and immune system dysregulation could potentially link these conditions to eczema.

3. High Blood Pressure

Research suggests a connection between eczema and high blood pressure, although the underlying mechanisms remain unclear.

Chronic inflammation and stress responses within the body may contribute to the development of both conditions.

4. Stroke

Recent studies have highlighted a potential association between eczema and an increased risk of stroke.

Inflammation, endothelial dysfunction, and vascular abnormalities may play a role in this connection.

5. Eating Disorders: Bulimia and Binge-Eating Disorders

Surprisingly, eating disorders such as bulimia and binge-eating disorders have been found to have links with eczema.

Psychological stress, nutrient deficiencies, and inflammation could contribute to this relationship.

6. Digestive Disorders: Ulcerative Colitis, Crohn’s Disease, and Others

Several digestive disorders, including ulcerative colitis and Crohn’s disease, have been associated with eczema.

Disruptions in gut microbiota, intestinal inflammation, and immune system dysfunction may be involved in the shared pathogenesis of these conditions.

7. Skin Disorders: Vitiligo and Alopecia Areata

Eczema has been observed alongside other skin disorders, including vitiligo (loss of skin pigmentation) and alopecia areata (patchy hair loss).

Genetic factors, autoimmune mechanisms, and immune system dysregulation may contribute to the co-occurrence of these conditions.

8. Neurological Conditions: Epilepsy

Emerging evidence suggests a potential association between eczema and epilepsy.

While the exact mechanisms are not fully understood, dysfunctions in the immune system, neuroinflammation, and genetic factors might play a role in this relationship.

9. Neurodevelopmental Disorders: Autism and ADHD

Research has indicated an increased prevalence of eczema in individuals with autism and attention-deficit/hyperactivity disorder (ADHD).

Shared genetic factors, immune dysregulation, and alterations in the skin barrier function may contribute to these associations.

10. Autoimmune Diseases: Rheumatoid Arthritis, Lupus, Multiple Sclerosis, and Others

Eczema has been found to coexist with various autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.

Autoimmune dysregulation, chronic inflammation, and shared genetic predispositions may underlie these connections.

11. Metabolic Conditions: Diabetes and Obesity

Studies have suggested a link between eczema and metabolic conditions, including diabetes and obesity.

Insulin resistance, chronic inflammation, and dysregulation of adipokines (hormones secreted by fat cells) could be potential factors linking these conditions.

The Importance of Identifying Underlying Causes

Identifying all potential underlying causes that trigger eczema flares is crucial for effective management and treatment.

While allergies and asthma are well-known triggers, the broader range of conditions discussed in this article highlights the need for a comprehensive evaluation.

Recognizing and addressing these underlying causes can help improve symptom control and enhance the quality of life for individuals with eczema.